Table 2.
Association of eight candidate SNPs with NBS IRT values in 111 subjects from Colorado.
| SNP | Chromosome | Positiona | Gene | Risk Alleleb | Risk Allele Frequency | P value | β (95% CI) | R2 |
|---|---|---|---|---|---|---|---|---|
| rs7512462 | 1 | 204166218 | SLC26A9 | T | 0.57 | 1.16 × 10−3 | −49 (−78, −20) | 0.09 |
| rs4077468 | 1 | 204181380 | SLC26A9 | T | 0.55 | 7.20 × 10−3 | −38 (−66, −11) | 0.06 |
| rs12047830 | 1 | 204183322 | SLC26A9 | C | 0.50 | 1.92 × 10−3 | −47 (−77, −18) | 0.08 |
| rs7419153 | 1 | 204183932 | SLC26A9 | T | 0.37 | 0.02 | −34 (−63, −5) | 0.05 |
| rs17563161 | 5 | 550624 | SLC9A3 | T | 0.28 | 0.50 | 13 (−24, 49) | 0.00 |
| rs12839137 | X | 115479578 | SLC6A14 | C | 0.84 | 0.87 | −3 (−39, 32) | 0.00 |
| rs5905283 | X | 115479909 | SLC6A14 | C | 0.63 | 0.21 | −16 (−42, 10) | 0.01 |
| rs3788766 | X | 115480867 | SLC6A14 | T | 0.73 | 0.41 | −12 (−40, 17) | 0.01 |
CI, Confidence Interval
a
: Based on Genome Reference Consortium Human Reference 37/Human Genome 19.
b
: Meconium ileus risk allele from Sun et al16.