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. 2015 Jul 7;34(3):1121–1128. doi: 10.3892/or.2015.4112

Figure 1.

Figure 1

SOX18 is overexpressed in HCC tissues. (A) SOX18 mRNA level was significantly higher in HCC than that in non-tumorous tissues from patients admitted to Shanxi Dayi Hospital between 2006 and 2008 (P<0.0001). (B) SOX18 expression was significantly increased in the HCC tissues when compared with the adjacent tissues of patients from the TCGA dataset. (C) Kaplan-Meier survival analysis of HCC patients. The survival time of patients with a low SOX18 expression level was notably longer than that of patients with high SOX18 expression (P<0.01). (D and E) The SOX18 expression level in five HCC cell lines was analyzed by western blot analysis and real-time PCR. The silencing effect of SOX18-siRNA was evaluated by western blot analysis and real-time PCR in the MHCC-97H (F and G) and HepG2 (H and I) cells. WT, wild-type cells; NC, cells transfected with scrambled siRNA; siRNA, cells transfected with SOX18-siRNA. Data are based on at least 3 independent experiments and are shown as mean ± SD (**P<0.01 as compared with NC).