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. 2015 Jul 7;34(3):1121–1128. doi: 10.3892/or.2015.4112

Figure 4.

Figure 4

Effect of SOX18 on the expression of RhoA, PDGFB, IGF1R, CCL2, CCL3 and CCL5 in HCC cells. (A and B) GSEA identified KEGG focal adhesion and chemokine signaling pathways as regulatory targets of SOX18. After 48 h of SOX18 siRNA treatment, the protein levels of the indicated genes in the MHCC-97H (C and D) and HepG2 cells (F and G) were analyzed by western blot analysis. GAPDH was also detected as the control for sample loading. The mRNA levels of the indicated genes in the MHCC-97H (E) and HepG2 cells (H) were analyzed by real-time PCR. Data are based on at least three independent experiments and are shown as mean ± SD (*P<0.05, **P<0.01 and ***P<0.001 as compared with NC).