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. 2015 Jul 1;34(3):1153–1161. doi: 10.3892/or.2015.4099

Figure 4.

Figure 4

miR-130a directly targets RUNX3. (A) miR-130a expression was detected in the AGS gastric cell line after transfecting anti-miR-130a and cont-miR. *P=0.0018 compared to the controls. (B) Smad4 and RUNX3 expression was examined by western blotting in the AGS gastric cell line following transfection with anti-miR-130a and cont-miR. *P=0.031 and #p=0.322 compared to the controls. (C) The relative luciferase activity was analyzed after the reporter plasmids were co-transfected with miR-130a mimics or control mimics into the AGS cell lines. *P=0.019 and #p=0.462 compared to the controls. (D) RUNX3 protein expression was examined by western blotting in gastric cancer tissues and the correlation between miR-130a and RUNX3 protein expression is shown. RUNX3, runt-related transcription factor 3.