Table 2. Genotypic and allelic associations of GAPDH variants with PD.
| SNP | Cases (n = 302) | Controls (n = 377) | OR (95% CI) | P-value | P-value a |
|---|---|---|---|---|---|
| N (%) | N (%) | ||||
| rs3741918 | |||||
| Genotype | |||||
| AA | 34 (11.3) | 56 (14.9) | |||
| AT | 139 (46.0) | 199 (52.8) | |||
| TT | 129 (42.7) | 122 (32.4) | |||
| Additive model | 0.73 (0.58–0.92) | 0.005 | 0.018 | ||
| Allele | |||||
| A | 207 (34.3) | 311 (41.2) | 0.74 (0.59–0.93) | 0.007 | 0.028 |
| T | 397 (65.7) | 443 (58.8) | |||
| rs1060619 | |||||
| Genotype | |||||
| TT | 95 (31.5) | 78 (20.7) | |||
| CT | 148 (49.0) | 201 (53.3) | |||
| CC | 59 (19.5) | 98 (26.0) | |||
| Additive model | 1.43 (1.15–1.79) | 4.17×10−4 | 0.002 | ||
| Allele | |||||
| T | 338 (56.0) | 357 (47.3) | 1.41 (1.14–1.75) | 0.002 | 0.007 |
| C | 266 (44.0) | 397 (52.7) |
a Adjusted by Bonferroni correction for multiple testing.