Fig 2. Experiment 2 Design and Timeline: Comparison of ASSRs after acute and continuous subchronic administration of PCP.

On day 1, all rats were subcutaneously injected with saline and baseline ASSRs were recorded. Ninety minutes later, control rats were injected with saline while experimental rats received an acute dose of PCP (5 mg/kg). On day 4, each rat was implanted with an osmotic mini pump that subcutaneously delivered either saline or PCP (5 mg/kg/day for 14 days). On day 18, ASSRs were recorded to assess the effect of chronic PCP exposure. After 25 days (7 days after cessation of drug delivery) washout ASSRs were obtained. Black regions in the time line indicate periods when the rats in the PCP arm received PCP.