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. 2015 Aug 10;10(8):e0135163. doi: 10.1371/journal.pone.0135163

Table 4. Integrated Analysis of miRNAs and their mRNA Targets after High Fat High Fructose Diet.

MicroRNA (Fold Change) Target mRNA Gene Symbol (Name) Fold Change
hsa-miR-186-5p (298) NAA38 (LSM8 homolog, U6 small nuclear RNA associated) -29.0
UBE2B (ubiquitin-conjugating enzyme E2B) -22.0
FAM204A (family with sequence similarity 204, member A) -7.8
EIF2S2 (eukaryotic translation initiation factor 2, subunit 2 beta) -4.4
MPC2 (mitochondrial pyruvate carrier 2) -3.3
ACTR10 (actin-related protein 10 homolog) -2.8
PDCD10 (programmed cell death 10) -2.8
hsa-miR-193b-3p (-15,448) SRSF6 (serine/arginine-rich splicing factor 6) 41.0
TRIB2 (tribbles pseudokinase 2) 12.0
UBP1 (upstream binding protein 1 (LBP-1a) 12.0
TAOK2 (TAO kinase 2) 7.0
SCARF1 (scavenger receptor class F, member 1) 6.0
GABPA (GA binding protein transcription factor, α subunit) 60kDa) 5.0
GPANK1(G patch domain and ankyrin repeats 1) 5.0
PPM1F (protein phosphatase, Mg2+/Mn2+ dependent, 1F) 5.0
STX16 (syntaxin 16) 5.0
ABI2 (abl-interactor 2) 4.0
CCNG2 (cyclin G2) 4.0
FGF12 (fibroblast growth factor 12) 4.0
CREBRF (CREB3 regulatory factor) 3.0
FAM53C (family with sequence similarity 53, member C) 3.0
RAPGEF5 (Rap guanine nucleotide exchange factor (GEF) 5) 3.0
RGL1 (ral guanine nucleotide dissociation stimulator-like 1) 3.0
ZBTB40 (zinc finger and BTB domain containing 40) 3.0
DLG1 (discs, large homolog 1 (Drosophila) 2.0
DYRK1A (dual-specificity TYR-(Y)-phos. regulated kinase 1A) 2.0
ERAP2 (endoplasmic reticulum aminopeptidase 2) 2.0
JAK2 (Janus kinase 2) 2.0
SLC23A2 (solute carrier family 23,ascorbiate transporter, member 2 2.0
ZNF562 (zinc finger protein 562) 2.0
hsa-miR-26a-5p (61,129) MSMO1 (methylsterol monooxygenase 1) -15.0
VMA21 (VMA21 vacuolar H+-ATPase homolog) -9.9
NT5DC1 (5'-nucleotidase domain containing 1) -9.0
MAT2A (methionine adenosyltransferase II, alpha) -6.0
BCCIP (BRCA2 and CDKN1A interacting protein) -4.9
MTFMT (mitochondrial methionyl-tRNA. Fformyltransferase) -4.6
B4GALT4 (UDP-Gal:betaGlcNAc beta 1,4- GST, polypeptide 4 -3.4
MCUR1 (mitochondrial calcium uniporter regulator 1) -3.0
PDCD10 (programmed cell death 10) -2.8
SRP19 (signal recognition particle 19kDa) -2.6
hsa-miR-28-3p (4,831) BCCIP (BRCA2 and CDKN1A interacting prtein) protein -4.9
PARL (presenilin associated, rhomboid-like) -4.8
hsa-miR-486-5p (-25,555) PTEN (phosphatase and tensin homolog) 6.0
FLRT2 (fibronectin leucine rich transmembrane protein 2) 5.0
ARHGAP5 (Rho GTPase activating protein 5) 4.0
ZNF701 (zinc finger protein 701) 4.0
GRAP (GRB2-related adaptor protein) 3.0
TEK (TEK tyrosine kinase, endothelial) 3.0
TTC31 (tetratricopeptide repeat domain 31) 3.0
VPS37B (vacuolar protein sorting 37 homolog B) 3.0
DYRK1A (dual-specificity TYR-(Y)-phos. regulated kinase 1A) 2.0
PPP1R16A (protein phosphatase 1, regulatory subunit 16A) 2.0