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. Author manuscript; available in PMC: 2015 Aug 10.
Published in final edited form as: J Pharmacol Sci. 2014 Apr 19;125(1):6–38. doi: 10.1254/jphs.13r04cr

Figure 3.

Figure 3

A: Comparison of INCX dynamics in different pacemaker cell models. A: Only Maltsev-Lakatta model (10), featuring Ca2+ clock, exhibits substantial increase in diastolic INCX. Modified from (44). B: In contrast to Kurata et al. model (66) (dotted curves), the ML model (solid curves) exhibits strong increase of inward INCX during DD clearly before activation of ICaL. The cycle lengths were 307.5 ms and 333 ms for Kurata et al. model and the Maltsev-Lakatta model, respectively. The vertical dash-dot line of 75% of cycle length illustrates approximate timing for ICaL activation. Modified from (10).