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. Author manuscript; available in PMC: 2015 Aug 10.
Published in final edited form as: J Pharmacol Sci. 2014 Apr 19;125(1):6–38. doi: 10.1254/jphs.13r04cr

Figure 5.

Figure 5

Effect of a specific reduction of If on AP firing rate is mediated via perturbation of both M-clock and Ca2+ clock. Simulations using the Maltsev-Lakatta model (10) with integrated mitochondrial Ca2+ dynamics predict the effects of IVA on (A) If, (B) AP, (C) ICaL, (D) cytosolic Ca2+, (E) junctional, (F) network SR [Ca2+], and (G) sarolemmal INCX. “Control”: model simulations prior to drug. “Change only in If”: model simulations when only If conductance is reduced. “Change in If and SERCA”: model simulations when both If and SR Ca2+ pumping (SERCA) parameters were changed. The dashed lines represent the respective diastolic DD phases. From (71).