Table 3.
Observed and corrected significance values of tests. The list of observed p-values is sorted from smallest to largest (indicated by the Rank column). All tests above and including those bolded meet significance at p<0.05 for various corrections for multiple hypothesis testing. Corrected significance thresholds at p<0.05 are listed using two controlling procedures: Bonferroni and False Discovery Rate (FDR) using the procedure of Benjamini and Hochberg (BH, (Benjamini, 1995)). Bolded values meet significance at p<0.05 for the various correction procedures.
| Test | Mean Difference | SE | Observed P-value | Rank (i) | Bonferroni threshold | FDR (BH) thresholds |
|---|---|---|---|---|---|---|
| Pre- vs. post-trauma DNMT3B in Cases |
1.51 | 0.35 | 0.000 | 1 | 0.002 | 0.002 |
| Pre- vs. post-trauma DNMT3B in Controls |
1.51 | 0.38 | 0.000 | 2 | 0.002 | 0.003 |
| Pre- vs. post-trauma DNMT1 in Cases |
0.84 | 0.22 | 0.001 | 3 | 0.002 | 0.005 |
| Pre- vs. post-trauma DNMT3A in Controls |
3.38 | 0.99 | 0.002 | 4 | 0.002 | 0.006 |
| Pre- vs. post-trauma DNMT3A in Cases |
2.41 | 0.86 | 0.009 | 5 | 0.002 | 0.008 |
| Cases vs. Controls DNMT3B (CpG 9) pre-trauma |
0.77 | 0.34 | 0.032 | 6 | 0.002 | 0.009 |
| CpG 9 Regression analysis (all symptoms) | B: −2.318 | 1.251 | 0.034 | 7 | 0.002 | 0.011 |
| Cases vs. Controls DNMT3B (CpG 2) pre-trauma |
0.19 | 0.11 | 0.057 | 8 | 0.002 | 0.013 |
| Pre- vs. post-trauma DNMT1 in Controls |
0.56 | 0.30 | 0.067 | 9 | 0.002 | 0.014 |
| CpG 9 Regression analysis (Intrusion symptoms) | B: −0.851 | 0.458 | 0.071 | 10 | 0.002 | 0.016 |
| Cases vs. Controls DNMT3B (CpG 12) pre-trauma |
0.44 | 0.24 | 0.122 | 11 | 0.002 | 0.017 |
| Cases vs. Controls DNMT3B (CpG 10) pre-trauma |
0.28 | 0.19 | 0.127 | 12 | 0.002 | 0.019 |
| Pre- vs. post-trauma DNMT3L in Cases |
0.74 | 0.47 | 0.132 | 13 | 0.002 | 0.020 |
| Cases vs. Controls DNMT3B pre-trauma |
0.27 | 0.17 | 0.135 | 14 | 0.002 | 0.022 |
| CpG 9 Regression analysis (Avoidance symptoms) | B: −0.821 | 0.541 | 0.137 | 15 | 0.002 | 0.023 |
| Cases vs. Controls DNMT3B (CpG 1) pre-trauma |
0.35 | 0.23 | 0.151 | 16 | 0.002 | 0.025 |
| Cases vs. Controls DNMT3B (CpG 8) pre-trauma |
0.50 | 0.33 | 0.158 | 17 | 0.002 | 0.027 |
| Cases vs. Controls DNMT3L pre-trauma |
0.91 | 0.65 | 0.176 | 18 | 0.002 | 0.028 |
| Cases vs. Controls DNMT3B (CpG 5) pre-trauma |
0.25 | 0.19 | 0.221 | 19 | 0.002 | 0.030 |
| CpG 9 Regression analysis (Hyperarousal symptoms) | B: −0.466 | 0.399 | 0.249 | 20 | 0.002 | 0.031 |
| Pre- vs. post-trauma DNMT3L in Controls |
0.36 | 0.32 | 0.261 | 21 | 0.002 | 0.033 |
| Cases vs. Controls DNMT3L post-trauma |
0.58 | 0.56 | 0.304 | 22 | 0.002 | 0.034 |
| Cases vs. Controls DNMT1 post-trauma |
−0..19 | 0.19 | 0.323 | 23 | 0.002 | 0.036 |
| Cases vs. Controls DNMT3B post-trauma |
0.18 | 0.22 | 0.351 | 24 | 0.002 | 0.038 |
| Cases vs. Controls DNMT3A post-trauma |
0.56 | 0.66 | 0.356 | 25 | 0.002 | 0.039 |
| Cases vs. Controls DNMT3B (CpG 7) pre-trauma |
0.11 | 0.12 | 0.487 | 26 | 0.002 | 0.041 |
| Cases vs. Controls DNMT1 pre-trauma |
0.09 | 0.20 | 0.565 | 27 | 0.002 | 0.042 |
| Cases vs. Controls DNMT3A pre-trauma |
−0.41 | 0.73 | 0.567 | 28 | 0.002 | 0.044 |
| Cases vs. Controls DNMT3B (CpG 6) pre-trauma |
0.11 | 0.17 | 0.603 | 29 | 0.002 | 0.045 |
| Cases vs. Controls DNMT3B (CpG 3) pre-trauma |
0.06 | 0.15 | 0.711 | 30 | 0.002 | 0.047 |
| Cases vs. Controls DNMT3B (CpG 11) pre- trauma |
0.11 | 0.39 | 0.773 | 31 | 0.002 | 0.048 |
| Cases vs. Controls DNMT3B (CpG 4) pre-trauma |
0.03 | 0.14 | 0.881 | 32 | 0.002 | 0.050 |
Note: For regression analyses, “B” represents unstandardized Beta values.