Table 1.
Patient demographic and clinical characteristics.
| Characteristics | Immunosuppressant | P value | |
|---|---|---|---|
| ATG (n=24) | FLU (n=32) | ||
| Age (years, range) | 45 (10–55) | 44 (13–57) | 0.353 |
| Gender (n,%) | |||
| Male | 15 (62.5) | 14 (43.8) | 0.452 |
| Female | 9 (37.5) | 18 (56.2) | 0.764 |
| Diagnosis (n,%) | |||
| Acute leukemia | 13 (54.2) | 20 (62.5) | 0.724 |
| AML | 8 (33.33%) | 12 (37.50) | 0.785 |
| ALL | 5 (20.83%) | 8 (25.00) | 0.760 |
| Multiple myeloma | 3 (12.5) | 4 (12.5) | 0.645 |
| CML | 4 (16.7) | 3 (9.3) | 0.823 |
| NHL | 2 (6.25) | 2 (6.4) | 0.942 |
| Primary myelofibrosis | 2 (6.25) | 3 (9.3) | 0.424 |
| HLA-mismatch (n, %) | |||
| 0 locus mismatch | 22 (91.6) | 29 (90.6) | 0.525 |
| 1 locus mismatch | 2 (8.4) | 3 (9.4) | 0.697 |
| Donor-patient sex match (n, %) | |||
| Sex-match | 10 (41.7) | 12 (37.5) | 0.486 |
| Sex-mismatch | 14 (58.3) | 20 (62.5) | 0.649 |
| ABO match (n,%) | |||
| Match | 6 (25.0) | 10 (31.3) | 0.278 |
| Mismatch | 18 (75.0) | 22 (68.7) | 0.629 |
| MNCs in DLI (×108/kg, range) | 1.15 (0.80–3.75) | ||
| CD3+ cells in DLI (×108/kg, range) | 0.45 (0.12–2.15) | ||
| CD4+ cells in DLI (×108/kg, range) | 0.25 (0.08–0.85) | ||
| CD34+ cells in DLI (×108/kg, range) | 0.45 (0.05–5.75) | ||
| Sources of stem cells (n, %) | |||
| PB | 12 (50.0) | 15 (46.9) | 0.468 |
| BM | 3 (12.5) | 4 (12.5) | 0.376 |
| BM+PB | 9 (37.5) | 13 (40.6) | 0.287 |
| Stem cells infused (mean ±SD) | |||
| CD34+ cells infused (×106/kg) | 4.5±2.2 | 4.8±2.1 | 0.569 |
| MNCs infused (×108/kg) | 6.4±2.2 | 6.5±2.5 | 0.247 |
| Profile of peripheral blood post-transplant (mean ±SD) | |||
| Lowest WBC count (×109/L) | 0.151±0.095 | 0.095±0.085* | 0.0242 |
| ANC ≥0.5×109/L (d) | 14.5±6.4 | 13.5±6.5 | 0.5687 |
| BPC ≥20×109/L (d) | 10.6±4.6 | 11.4±5.6 | 0.5710 |
| BPC ≥50×109/L (d) | 14.6±6.6 | 18.5±4.5* | 0.0111 |
| Infused volume (U) | |||
| RBC | 6.3±4.5 | 4.2±2.5* | 0.0303 |
| Platelet | 9.2±3.5 | 6.4±2.5** | 0.0010 |
FLU – fludarabine; ATG – anti-thymocyte globulin; DLI – donor lymphocyte infusion; HSCT – hematopoietic stem cell transplantation; HLA – human leucocyte antigen; MNC – mononuclear cell; CML – chronic myeloid leukemia; PB – peripheral blood; BM – bone marrow; NHL – non-Hodgkin lymphoma; RBC – red blood cell; NSCT – non-myeloablative stem cell transplantation; BPC – blood platelet count; WBC – white blood cell; ANC – absolute neutrophil count.
*
0.05>P>0.01,
**
P< 0.01.