Table 1.
Past medical history of the participants in two groups of the clinical trial comparing effect of flutamide and hydroquinone on melasma
| Clinical history | Trial group | Current suffering frequency (%) | Previous history frequency (%) | Not suffered frequency (%) |
|---|---|---|---|---|
| Menstrual irregularities | Flutamide | 13 (37.1) | 3 (8.6) | 19 (54.3) |
| Hydroquinone | 9 (24.3) | 4 (10.8) | 24 (64.9) | |
| Total | 22 (30.6) | 7 (9.7) | 19 (54.3) | |
| Ovarian cysts | Flutamide | 2 (6.1) | 8 (24.3) | 23 (69.7) |
| Hydroquinone | 3 (8.3) | 8 (22.2) | 25 (69.4) | |
| Total | 5 (7.25) | 16 (23.2) | 48 (69.6) | |
| Infertility | Flutamide | 1 (3.45) | 1 (3.45) | 27 (93.1) |
| Hydroquinone | 3 (12) | 0 (0) | 22 (88) | |
| Total | 4 (7.4) | 1 (1.85) | 49 (90.7) | |
| Hair loss | Flutamide | 14 (41.2) | 1 (2.9) | 19 (55.9) |
| Hydroquinone | 11 (31.4) | 0 (0) | 24 (68.6) | |
| Total | 25 (36.2) | 1 (1.45) | 43 (62.3) | |
| History of Addison’s disease, Cushing’s syndrome, or hyperthyroidism | Only one patient in the flutamide group had history of hyperthyroidism | |||
| Drug history | ||||
| History of OCP usage | Flutamide | Yes: 20 (55.6) | No: 16 (44.4) | |
| Hydroquinone | Yes: 12 (32.4) | No: 25 (67.6) | ||
| Total | Yes: 32 (43.8) | No: 41 (56.2) | ||
| History of spironolactone usage | Flutamide | Yes: 1 (2.8) | No: 35 (97.2) | |
| Hydroquinone | Yes: 0 (0) | No: 37 (100) | ||
| Total | Yes: 1 (1.4) | No: 72 (98.6) | ||
| History of phenytoin usage | No one reported use of phenytoin among participants | |||
| Family history | ||||
| Hirsutism in mother | Flutamide | Yes: 0 (0) | No: 35 (100) | |
| Hydroquinone | Yes: 3 (8.1) | No: 34 (91.9) | ||
| Total | Yes: 3 (4.2) | No: 69 (95.8) | ||
| Melasma in mother | Flutamide | Yes: 4 (11.1) | No: 32 (88.9) | |
| Hydroquinone | Yes: 8 (21.6) | No: 29 (78.4) | ||
| Total | Yes: 12 (16.4) | No: 61 (83.6) | ||
| Hirsutism in sister | Flutamide | Yes: 9 (25.7) | No: 26 (74.3) | |
| Hydroquinone | Yes: 6 (16.2) | No: 31 (83.8) | ||
| Total | Yes: 15 (20.8) | No: 57 (79.2) | ||
| Melasma in sister | Flutamide | Yes: 20 (55.6) | No: 16 (44.4) | |
| Hydroquinone | Yes: 26 (70.3) | No: 11 (29.7) | ||
| Total | Yes: 46 (63) | No: 27 (37) | ||
| Hirsutism in either one of mother, sister, or aunts | Flutamide | Yes: 11 (31.4) | No: 24 (68.6) | |
| Hydroquinone | Yes: 9 (24.3) | No: 28 (75.7) | ||
| Total | Yes: 20 (27.8) | No: 52 (68.6) | ||
| Melasma in either one of mother, sister, or aunts | Flutamide | Yes: 24 (66.7) | No: 12 (33.3) | |
| Hydroquinone | Yes: 31 (83.8) | No: 6 (16.2) | ||
| Total | Yes: 55 (75.3) | No: 18 (24.7) | ||
Abbreviation: OCP, oral contraceptive pill.