Fig 4.

Pseudo-longitudinal measurements of telomere shortening in the UK Twins cohort. Because the difference in telomere length between the first and second twin measured is zero on average in twins measured at nearly the same time, the measurement of twins years apart may be considered a better measurement of telomere shortening rate. Pseudo-longitudinal telomere shortening in the UK Twins cohort is more consistent with the mediation-adjusted model (gray line) than simple cross-sectional analysis. The 95% confidence interval of the pseudo-longitudinal regression is demarcated by dotted lines.