Table 2.
Mediation-adjusted models
| Independent variable | Mediation (bp/year) | Total mediation | Adjusted coefficient | ||
|---|---|---|---|---|---|
| Age | PBY | FAB | |||
| UK Twins | |||||
| Age | N/A | 20.26 | 0.70 | 20.95 | −41.64 |
| PBY | 31.58 | N/A | −7.10 | 24.47 | −12.38 |
| FAB | −4.50 | −23.19 | N/A | −27.69 | 36.58 |
| NHLBI-FHS | |||||
| Age | N/A | 15.12 | 0.39 | 15.51 | −36.81 |
| PBY | 27.47 | N/A | −8.72 | 18.75 | −5.94 |
| FAB | −1.90 | −23.41 | N/A | −25.31 | 37.97 |
| Asklepios | |||||
| Age | N/A | 20.12 | 2.37 | 22.49 | −48.42 |
| PBY | 20.82 | N/A | −24.02 | −3.20 | 6.29 |
| FAB | −14.08 | −41.06 | N/A | −55.14 | 58.23 |
| Combined | |||||
| Age | N/A | 18.00 | 0.74 | 18.75 | −40.19 |
| PBY | 28.10 | N/A | −10.04 | 18.06 | −7.18 |
| FAB | −3.05 | −23.77 | N/A | −26.82 | 38.62 |
The effect of each independent variable (age, PBY, and FAB) is adjusted for the effects of each other independent variable on telomere length and their collinearity within each dataset. The adjusted coefficients (far right) illustrate age-associated telomere shortening rates consistent with longitudinal observations, heterogeneity in PBY effects and reveal larger FAB effects than previously reported.