| Haggstrom, H. 2012 [39] |
Me-Can cohort |
Prospective cohort |
289,866 men included. |
Smoking status, BMI, blood pressure, glucose, cholesterol, and TG. |
PCa risk |
High levels of triglycerides were associated with a decreased risk of pca top quintile RR 1.24 (1.06–1.45) bottom quintile 0.88 (0.74–1.04). |
Smoking, BMI. |
| Jacobs, E.J.2012 [40] |
Cancer prevention study II nutrition cohort |
Cohort. |
236 cases and 236 matched controls. |
TC, LDL cholesterol, HDL cholesterol, non-HDL cholesterol. (non-fasting). |
PCa risk |
Neither total, LDL, nor HDL cholesterol concentrations were associated with risk of pca. OR 0.93 (95% CI 0.76–1.14) for total cholesterol and 0.97 (95% CI 0.82–1.16) |
Age, race, blood draw date, physical activity, use of cholesterol-lowering drugs, and history of heart attack. |
| His, M 2014. [49] |
Supplementation en vitamines et mineraux antioxydants study |
Cohort |
7557 subjects |
TC, LDL cholesterol, HDL cholesterol, TG, ApoA1, apob |
Breast cancer and PCa risk |
TC was inversely associated with overall (HR = 0.91 95% CI 0.82–1.00) and breast (HR = 0.83 95% CI 0.69–0.99) cancer risk. HDL-c was also inversely associated with overall (HR = 0.61 95% CI 0.46–0.82) and breast (HR = 0.48 95% CI 0.28–0.83) cancer risk. Consistently apoa1 was inversely associated with overall (HR = 0.56 95% CI 0.39–0.82) and breast (HR = 0.36 95% CI 0.18–0.73) cancer risk. |
Age, intervention group, number of dietary records, alcohol intake per day, physical activity. Smoking status, educational level, height, BMI, family history of bca, menopausal status at baseline, TG-lowering drugs antihypertensive drugs, energy intake per day and glycaemia. Ratio models adjusted for TG and TC. |
| Wu, Q. 2012 [48] |
Hospital PUMCH patient information database |
Case-control |
210 pancreatic adenocarcinoma, 630 healthy controls |
TC, LDL cholesterol, HDL cholesterol, TG, ApoA1, apob, fasting blood glucose. |
Pancreatic adenocarcinoma risk |
TC (OR–1.793 95% 1.067–3.013) and ApoA (OR = 36.065 95% 15.547–83.663) were significantly related to pancreatic adenocarcinoma. |
Age and sex. |
| Agnoli, C. 2014 [41] |
Colorectal cancer cases |
Cohort |
1134 participants 850 in randomly selected cohort and 286 colorectar cancer cases |
TC, LDL cholesterol, HDL cholesterol, TG. (Fasting) |
Colorectal cancer risk |
Highest tertiles of total (HR = 1.66 95% 1.12–2.45) and LDL cholesterol (HR1.87 95% CI 1.27–2.76) were associated with increased colorectal cancer risk. |
Age, gender, BMI, smoking, total physical activity, alcohol consumption, dietary red meat, dietary fiber, and dietary calcium. |
| Jiang, R. 2014 [51] |
Cancer registry |
Cohort |
807 patients. |
TC, LDL cholesterol, HDL cholesterol, TG, ApoA1, ApoB, |
Nasopharyngeal carcinoma survival |
ApoA-I levels (HR = 0.64 95% CI 0.52–0.80) were associated with a favourable OS. |
Adjustment for clinical characteristics and other serum lipids and lipoproteins |
| Kim, H.S.2013 [42] |
|
Cohort |
14932 |
BMI, H.pylori, TC, LDL-c, HDL-c, TG |
Prevalence and risk factors of colorectal cancer |
Predictor of colorectal cancer was hypertriglyceridemia (OR = 1.267 95% CI 1.065–1.508) |
– |
| Shafique, K. 2012 [38] |
Midspan studies |
Prospective cohort study |
12,926 men (650 cases) |
Baseline cholesterol |
Incidence of pca and prognosis |
Baseline plasma cholesterol was associated with hazard of high grade PCa incidence (n = 119). |
Association remained significant after adjustment for body mass index, smoking and socioeconomic status |
| Kitahara et al 2011 [35] |
Korean adults enrolled in the National Health Insurance Corporation |
Cohort |
53,944 men and 24,475 women |
TC (fasting) |
Cervix, breast, colon, lung, pancreas, bladder, kidney, oesophagus, gall bladder, liver, rectal, prostate cancer risk |
TC (≥ 240 mg/dL) was associated with PCa (HR 1.24; 95% CI, 1.07 –1.44; P = 001) and colon cancer (HR, 1.12; 95% CI, 1.00–1.25; P = 05) in men. Breast cancer (HR, 1.17; 95% CI, 1.03 –1.33; P trend = 03). Total cholesterol was inversely associated with all-cancer incidence in both men (HR, 0.84; 95% CI, 0.81–0.86; P < 001) and women (HR, 0.91; 95% CI, 0.87–0.95; P < .001). |
Adjustments for cigarette smoking, alcohol consumption, BMI, physical activity, hypertension and fasting serum glucose . |
| Mondul et al, 2011 [37] |
ATBC Study |
Cohort |
2041 |
TC, HDL (fasting) |
PCa risk |
Men with higher serum TC were at increased risk of overall (≥ 240 versus <200 mg/dl: HR = 1.22, 95% CI 1.03–1.44, ptrend = 0.01) and advanced (≥240 versus<200 mg/dL: HR = 1.85, 95% CI 1.13–3.03, p-trend = 0.05) prostate cancer |
Adjusted for serum α-tocopherol, family history of prostate cancer, education level, and urban residence, other cholesterol type, smoking habits, BMI, marital status; total energy, total fat, fruit, vegetable, red meat, alcohol, dietary retinol, vitamin D, calcium intake. Subgroup analyses were conducted stratifying by follow-up time (<ten years, >ten years). |
| Kok et al, 2011 [36] |
Nijmegen Biomedical Study |
Cohort |
2842 |
TG, TC, HDL, LDL |
PCa risk |
Higher total and higher LDL cholesterol were significantly associated with an increased risk of prostate cancer HR 1.39 (95% CI 1.03–1.88) and 1.42 (95% CI 1.00–2.02), respectively. Similar results were observed for aggressive prostate cancer, whereas for non-aggressive prostate cancer a significant association with HDL cholesterol was found HR 4.28, 95% CI 1.17–5.67. |
Adjusted for age, body mass index and history of diabetes mellitus |
| Agnoli et al, 2010 [47] |
Cancer registry |
Cohort |
163 |
TG, HDL |
Breast cancer risk |
Metabolic syndrome associated with breast cancer risk (rate ratio 1.58 [95% confidence interval 1.07–2.33]), Low serum HDL-cholesterol and high triglycerides were significantly associated with increased risk |
Adjusted for matching variables and for: age, age at menarche, years from menopause, number of full-term pregnancies, age at first birth, oral contraceptives, hormone therapy, years of education, history of breast cancer in first degree relatives, breastfeeding, smoking, and alcohol consumption. |
| Bjorge et al, 2011 [50] |
Me-Can study |
Cohort |
644 |
TG, TC (fasting and non-fasting) |
Ovarian cancer |
– |
Year of birth, age at measurement, smoking and quintile levels of BMI |
| Van Duijnhoven et al, 2011 [43] |
EPIC study |
Nested case-control (EPIC) |
1238 |
TG, TC, HDL, LDL, Apo A-1, Apo B (NS) |
Colorectal cancer risk |
HDL and apoA were inversely associated with the risk of colon cancer (RR for 1 SD increase of 16.6 mg/dl in HDL and 32.0 mg/dl in apoA of 0.78 (95% CI 0.68–0.89) and 0.82 (95% CI 0.72-0.94), respectively. |
Height, weight, smoking habits, physical activity, education, consumption of fruit, vegetables, meat, fish and alcohol, intake of fibre, energy from fat and energy from non-fat |
| Hu et al, 2011 [43] |
Cancer registry |
Case-control |
397 |
TG, HDL (fasting) |
Colorectal cancer risk |
TGs associated with cancer risk ·HR for ≥150mg/dl vs <150mg/dL:1.18; 95% CI: 0.9–1.51. HDL (-):· HR for < 40mg/dL versus ≥40mg/dL (men) or <50 mg/dL versus ≥ 50mg/dL (women): 0.94; 95% CI: 0.71–1.24. |
Age, sex, smoking, drinking, past history of adenoma, other components of metabolic syndrome. |
| Aleksandrova et al 2011 [45] |
EPIC study |
Nested case-control(EPIC) |
689 |
TG, HDL, (fasting and non-fasting) |
Colon, rectal, cancer risk |
Reduced HDL associated with colon cancer risk RR for ≤ 40 mg/dL versus > 40mg/dL in men and ≤ 50mg/dL versus > 50mg/dL in women: 1.36; 95% CI: 1.04–1.77. |
Smoking status, education, alcohol consumption, physical activity, fiber intake, consumption of fruits and vegetables, red and processed meat, fish, and shellfish. |
| Stocks et al, 2011 [46] |
Me-Can study |
Cohort |
2834 men, 1861 women |
TG, TC (fasting and non-fasting |
Colorectal cancer risk |
TGs were found to be positively associated with cancer risk RR for fifth versus first quintile: 1.65; 95% CI: 1.27–2.13 (men), RR for fifth versus first quintile: 1.42; 95% CI: 1.09–1.85 (women).). |
Smoking, five categories of birth year, age at measurement and quintiles of BMI |
