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. 2015 Jul 23;9:555. doi: 10.3332/ecancer.2015.555

Table 5. Epidemiological studies on bone metabolism and cancer.

Publication Study population Study design No. of subjects, follow-up Exposure Outcome Main results Adjustments
Brandstedt, 2012 [159] The Malmo Diet and Cancer Study cohort, Sweden, men, born in 1923–1945 Case control 943 cases, 943 controls Serum total calcium Prostate cancer OR: 1.34 (0.78–1.39) for highest versus lowest quartile Matched on BMI, educational level, alcohol consumption, and smoking.
Schwartz, 2012 [160] National Health and Nutrition Examination Survey III (NHANES III), USA, age 18+ Cohort 6707 at baseline, 49 events, 1069327 person-months Serum total calcium Prostate cancer mortality HR: 1.50 (95% CI: 1.04–2.17) for every unit increase Adjusted for age and BMI, serum albumin, and serum 25-OHD and account for survey weights and the complex sampling design of NHANES III
Salem, 2013 [161] Iran, men, mean age 71.1 (cases) and 66.5 (controls) Case control 194 cases, 317 controls Serum total calcium Prostate cancer OR: 0.27 (0.12–0.59) for or highest versus lowest tertile Adjusted for age, body mass index, occupation, educational level, smoking, alcohol, family history of prostate cancer, and sex hormones. Similar results with albumin-corrected calcium