Table 1.

Overview of miRNA-regulated chemokines in atherosclerosis

miRNA	Target	Effector cell	Affected chemokine	Role in atherosclerosis	References
miR-181b	Importin-α3	ECs	CXCL1	Protective	[58]
miR-103	KLF4	ECs	CXCL1 CCL2	Damaging	Unpublished
miR-126-3p	RGS16	ECs	CXCL12	Protective	[64]
miR-10a	TAK1, β‐TRC	ECs	CCL2	Protective	[87]
miR-92a	KLF2, KLF4, SOCS5	ECs	CCL2 CXCL1?	Damaging	[88]
miR-21	PPARα	ECs	CCL2	Damaging	[79]
let-7g	THBS1, TGFBR1, SMAD2	ECs	CCL2	Protective	[97]
miR-155	BCL6	Macrophages	CCL2	Damaging	[43]
miR-342-5p	AKT1	Macrophages	CCL2 (via miR-155)	Damaging	[102]
miR-467b	LPL	Macrophages	CCL2	Protective	[105]
miR-24	CHI3L1	Macrophages	CCL2	Protective	[108]

miR/miRNA microRNA, RGS16 regulator of G-protein signaling 16, TAK1 transforming growth factor β-activated kinase 1, β‐TRC β‐transducin repeat‐containing gene, KLF2/4 Krüppel-like factor 2/4, SOCS5 suppressor of cytokine signaling 5, TLR4 toll-like receptor 4, TRAF6 TNF receptor-associated factor 6, IRAK1/2 interleukin-1 receptor-associated kinase 1/2, PPARα peroxisome proliferator-activated receptor α, THBS1 thrombospondin 1, TGFBR1 transforming growth factor, beta receptor 1, SMAD2 SMAD family member 2, Bcl6 B-cell lymphoma 6 protein, Akt1 v-akt murine thymoma viral oncogene homolog 1, CHI3L1 chitinase 3-like 1, LPL lipoprotein lipase