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. 2015 Jun 20;20(9):1135–1149. doi: 10.1007/s10495-015-1143-z

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — The subcellular shuttling of PHB during cell apoptosis. During the apoptosis of gonadotrope cells induced by GnRH and apoptosis of cancer cells induced by camptothecin or TGF-β, PHB1 is exported from the nucleus to the cytoplasm or mitochondria. However, during the apoptosis of cancer cells induced by abrin or ESC-3, PHB1 translocates from the cytoplasm or mitochondria to the nucleus. During the apoptosis of cancer cells induced by estradiol or capsaicin, PHB2 translocates from the cytoplasm or mitochondria to the nucleus