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. 2015 Aug 11;6:1133. doi: 10.3389/fpsyg.2015.01133

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Copyright © 2015 McInnis, McQuaid, Matheson and Anisman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of the moderated multiple mediation analyses examining parental unsupport. The relation between unsupportive social interactions from parents and depressive symptoms through problem-focused coping was moderated by oxytocin receptor gene (OXTR) rs53576 genotype, such that it was only significant among A carriers. As well, the relation between unsupportive responses from parents and depressive symptoms through emotion-focused coping as moderated by OXTR genotype. This mediated model was significant irrespective of genotype, but was stronger among A carriers. ^∗p ≤ 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001.