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. 2015 Aug 11;6:832. doi: 10.3389/fmicb.2015.00832

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Copyright © 2015 Balamurugan, Hema, Kaur, Sridharan, Prabu, Sumana and Princy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological analyses of kidney tissue sections. (E) Kidney section of rats inoculated with S. aureus and co-treated with the UTI^QQ (LD) showing minimal dilatation/degeneration of tubules (arrow). The presence of majority of the tubules in the adjacent areas showed no significant pathological changes. (F) Kidney section of the rats inoculated with S. aureus and co-treated with - UTI^QQ (HD) revealed moderate lympho-plasmacytic cell infiltration (arrow). (G) Kidney section of the rat inoculated with S. aureus and co-treated with the combinatorial drugs, gentamicin and UTI^QQ (LD) showed mild hyperplasia of the urothelium (arrow) and minimal amount of mononuclear cell infiltrates. (H) Kidney section of the rats inoculated with S. aureus and co-treated with gentamicin and UTI^QQ (HD) having minimal dilatation/degeneration of tubules with no significant inflammatory changes. (Gentamicin, LD, 8 mg/kg and HD, 50 mg/kg; Hybrid molecule UTI^QQ, LD, 16 mg/kg and HD, 64 mg/kg).