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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Mutat Res. 2014 Dec 3;776:9–15. doi: 10.1016/j.mrfmmm.2014.11.008

Figure 6.

Figure 6

Genomic lengths of human NER genes. (A) The lengths of the 29 human NER genes are expressed in kb. As can be seen, the MNAT1 is the longest gene followed by ERCC6, RPA3 and ERCC8. The median length of all human genes is 18 kb. (B) Model of how ERCC6/CSB may act as a dosimeter of DNA damage to ensure an appropriate level of cell death as a function of UV dose. At lower doses of UV light, cells are able to transcribe sufficient amounts of RNA from the ERCC6 gene to sustain CSB protein levels for proficient TC-NER. At higher levels of UV exposure, transcription-blocking lesions have a high likelihood of forming in the large ERCC6 gene resulting in the inhibition of new synthesis of ERCC6 RNA. Since the ERCC6 transcript is very unstable, it is expected that the levels of ERCC6 RNA will rapidly diminish as transcription of the gene is prohibited, resulting in a time-dependent loss of the CSB protein, loss of TC-NER and induction of cell death.