Skip to main content
. Author manuscript; available in PMC: 2016 Jan 16.
Published in final edited form as: Nature. 2015 Jul 8;523(7560):361–365. doi: 10.1038/nature14613

Extended Data Figure 8. Loss of Ste12 sites decreased in the Saccharomyces clade.

Extended Data Figure 8

The yeast phylogeny along with the number of Ste12 binding sites in extant species was used to estimate the gain and loss rate of the sites over evolutionary time. The Saccharomyces clade was allowed to have different rates (orange) (X2 = 49.33, df = 2, P = 1.94e-11). The gain and loss rate units are cis-regulatory sites per amino acid substitution in the species phylogeny.