Table 1.
Differentially expressed GPCRs in the antennae of fed and starved flies
| FlyBase ID | Gene | Gene name | Count ratio | p-value | FPKM starved |
|---|---|---|---|---|---|
| A. Receptors for biogenic amines and related compounds | |||||
| FBgn0011582 | DopR | Dopamine receptor | 1.52 | 0.000 | 2.59 |
| FBgn0053517 | D2R | Dopamine 2-like receptor | 1.32 | 0.001 | 1.63 |
| FBgn0038980 | oa2 | Octopamine receptor 2 | 1.29 | 0.000 | 19.64 |
| FBgn0038542 | TyrR | Tyramine receptor | 1.23 | 0.020 | 0.85 |
| FBgn0004168 | 5-HT1A | Serotonin receptor 1A | 1.21 | 0.000 | 8.27 |
| FBgn0250910 | Octbeta3R | Octbeta3R | 1.20 | 0.000 | 17.00 |
| FBgn0037546 | mAChR-B | muscarinic Acetylcholine Receptor, B-type | 1.18 | 0.000 | 10.28 |
| FBgn0004514 | Oct-TyrR | Octopamine-Tyramine receptor | 1.16 | 0.021 | 2.09 |
| FBgn0087012 | 5-HT2 | Serotonin receptor 2 | 1.15 | 0.000 | 10.50 |
| FBgn0024944 | Oamb | Octopamine receptor in mushroom bodies | 1.15 | 0.000 | 37.92 |
| FBgn0000037 | mAcR-60C | muscarinic Acetylcholine receptor 60C | 1.14 | 0.000 | 6.74 |
| FBgn0035538 | DopEcR | Dopamine/Ecdysteroid receptor | 1.08 | 0.000 | 133.42 |
| FBgn0015129 | DopR2 | Dopamine receptor 2 | 1.07 | 0.044 | 4.67 |
| FBgn0038063 | Octbeta2R | Octbeta2R | 0.79 | 0.003 | 1.30 |
| B. Peptide receptors | |||||
| FBgn0039396 | CcapR | Cardioacceleratory peptide receptor | 2.42 | 0.017 | 0.13 |
| FBgn0004622 | Takr99D | Tachykinin-like receptor at 99D | 1.67 | 0.029 | 0.28 |
| FBgn0003255 | rk | rickets | 1.50 | 0.000 | 0.98 |
| FBgn0033579 | CG13229 | – | 1.45 | 0.002 | 1.78 |
| FBgn0053696 | CNMaR | CNMamide Receptor | 1.44 | 0.019 | 0.51 |
| FBgn0036934 | sNPF-R | short neuropeptide F receptor | 1.41 | 0.000 | 7.26 |
| FBgn0028961 | AlstR | Allatostatin receptor | 1.30 | 0.011 | 0.85 |
| FBgn0035331 | DmsR-1 | Dromyosuppressin receptor 1 | 1.26 | 0.003 | 1.59 |
| FBgn0038880 | SIFR | SIFamide receptor | 1.20 | 0.000 | 2.78 |
| FBgn0259231 | CCKLR-17D1 | CCK-like receptor at 17D1 | 1.13 | 0.000 | 68.50 |
| FBgn0025631 | moody | moody | 1.09 | 0.000 | 50.86 |
| FBgn0016650 | Fsh | Fsh-Tsh-like receptor | 1.08 | 0.021 | 7.74 |
| FBgn0085410 | TrissinR | Trissin receptor | 1.06 | 0.025 | 15.30 |
| FBgn0038874 | ETHR | ETHR | 0.94 | 0.003 | 21.31 |
| FBgn0031770 | CG13995 | – | 0.91 | 0.000 | 15.93 |
| FBgn0004841 | Takr86C | Tachykinin-like receptor at 86C | 0.91 | 0.016 | 6.86 |
| FBgn0029723 | Proc-R | Proctolin receptor | 0.89 | 0.005 | 6.22 |
| FBgn0030954 | CCKLR-17D3 | CCK-like receptor at 17D3 | 0.79 | 0.000 | 8.62 |
| FBgn0025595 | AkhR | Adipokinetic hormone receptor | 0.74 | 0.000 | 11.06 |
| FBgn0038201 | Pk1r | Pyrokinin 1 receptor | 0.67 | 0.000 | 11.58 |
| FBgn0039354 | Lgr3 | Lgr3 | 0.51 | 0.000 | 0.24 |
| FBgn0039595 | AR-2 | Allatostatin receptor 2 | 0.39 | 0.002 | 0.11 |
| C. Metabotropic glutamate receptor family | |||||
| FBgn0050361 | mtt | mangetout | 3.27 | 0.000 | 0.54 |
| FBgn0019985 | mGluRA | metabotropic glutamate receptor | 1.94 | 0.000 | 1.14 |
| FBgn0052447 | CG32447 | – | 1.89 | 0.000 | 4.27 |
| FBgn0031275 | GABA-B-R3 | GABA-B receptor subtype 3 | 1.27 | 0.000 | 2.44 |
| FBgn0051760 | CG31760 | – | 1.17 | 0.000 | 6.36 |
| FBgn0051660 | pog | poor gastrulation | 1.16 | 0.000 | 34.68 |
| FBgn0260446 | GABA-B-R1 | GABA-B receptor subtype 1 | 1.16 | 0.000 | 33.18 |
| FBgn0085401 | CG34372 | – | 1.10 | 0.033 | 3.96 |
| FBgn0027575 | GABA-B-R2 | GABA-B receptor subtype 2 | 0.94 | 0.000 | 27.45 |
Each RNA sample was from the antennae of 200 female flies (w1118;+;Orco-Gal4/+). Count ratio is the number of reads aligned to each gene between starved and satiated flies. FPKM, fragment per kilobase of exon per million mapped fragments. p-values were calculated on raw counts using the Fisher's exact test in edgeR package.