Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Duration of crying
Systematic review	Infants (1–9 weeks of age) with colic 2 RCTs in this analysis	Mean change (hours/day) with spinal manipulation with no treatment Absolute results not reported	Mean difference –0.57 95% CI –2.24 to +1.09 P = 0.50 Significant heterogeneity, not further explained I2 = 75%		Not significant