Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Presence of colic
Systematic review	Infants (1–9 weeks of age) with colic 2 RCTs in this analysis	Presence of colic (as reported by parents on a Likert scale) 25/81 (31%) with spinal manipulation 10/74 (14%) with no treatment	OR 4.32 95% CI 0.12 to 157.98 P = 0.43 Significant heterogeneity, not further explained I2 = 89%		Not significant