Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Duration of crying
Systematic review	122 breastfed and formula-fed infants (4–16 weeks) with colic defined by Wessel's criteria Data from 1 RCT	% of infants experiencing 25% or greater reduction in total distress (minutes/day) 7 days 61% with hypoallergenic diet (maternal low allergen diet or hypoallergenic casein hydrolysate milk) 43% with standard care (control diet or cow's milk formula) Absolute numbers not reported	Adjusted OR 2.32 95% CI 1.07 to 5.0 P = 0.03	Moderate effect size	hypoallergenic diet/hypoallergenic casein hydrolysate milk
Systematic review	175 formula-fed infants (4–12 weeks) with colic defined by Wessel's criteria Data from 1 RCT	Reduction in mean total crying (hours/day) 7 days with extensively hydrolysed formula milk (35 infants) with cow's milk formula (35 infants) Absolute results not reported	P <0.001	Effect size not calculated	hydrolysed formula milk