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. Author manuscript; available in PMC: 2016 Jul 13.
Published in final edited form as: Cancer Cell. 2015 Jul 13;28(1):97–113. doi: 10.1016/j.ccell.2015.06.004

Figure 2. DNA-PKcs selectively impacts gene expression in CRPC.

Figure 2

(A) RNA harvested from C4-2 cells depleted of DNA-PKcs or treated with 1μM NU7441 (DNA-PKcsi) for 24 hrs was analyzed by microarray analysis (left). Immunoblot of phospho-S2056 DNA-PKcs, total DNA-PKcs, and Ku70 after knockdown or NU7441 treatment (right). (B) Genes identified as upregulated (left) or downregulated (right) by ≥1.5 fold compared to untreated. (C,D) GSEA motif (left) or gene ontology (right) analyses of all genes altered at least 1.5-fold after DNA-PKcs knockdown.

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