Figure 5. DNA-PKcs induces metastatic phenotypes.
(A) Cells depleted of DNA-PKcs were seeded into hormone deficient media and allowed to migrate (left) or invade through matrigel (right) towards hormone proficient media. (B) Cells pretreated with 1μM NU7441, SLx-2119 or combination of both for 24 hrs were seeded into hormone deficient media and allowed to migrate for 24 hrs (top) or invade through matrigel for 72 hrs (bottom) towards hormone proficient media. Data are reported as mean +/− SD. *p<0.05, **p<0.01 compared to control unless otherwise indicated. See also Fig S4.