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. 2015 Sep 1;38(9):1371–1380. doi: 10.5665/sleep.4972

Figure 4.

Figure 4

Effects of the Cacna1c haploinsufficiency on recovery sleep responses to restraint stress (RS). (A–D) Changes in nonrapid eye movement (NREM) sleep (%) and rapid eye movement (REM) sleep (%) in wild-type littermates (WT; n = 6, left panels) and heterozygous Cacna1c knockout mice (HET; n = 6, right panels) mice subjected to 1 h of restraint stress during the first hour of the light period. (E,F) Averaged REM sleep amount, (G,I) episode duration, and (H,J) occurrences of REM sleep during the first 6 h of the dark period (Zeitgeber time, 13–18 h). All values are mean ± standard error of the mean. Significant differences between baseline and recovery: *P < 0.05, **P < 0.01 (A–D; two-way analysis of variance [ANOVA], E–J; one-way ANOVA, Bonferroni multiple comparison post hoc test).