Table 1.

Response criteria for hepatocellular carcinoma target lesions

Response category	WHO	mRECIST
Complete response (CR)	Disappearance of all known disease	Disappearance of any intratumoral arterial enhancement in typical intrahepatic lesions and disappearance of all other target lesions
Partial response (PR)	≥50% decrease in the sum of the product of the two longest perpendicular diameters of target lesions (reference: baseline sum)	≥30% decrease in the sum of diameters of target lesions (two lesions per organ, maximum of five lesions) (reference: baseline sum)
Stable disease (SD)	Does not qualify for either PR or PD	Does not qualify for either PR or PD
Progressive disease (PD)	≥25% increase in the sum of the product of two longest perpendicular diameters (reference: smallest sum recorded since treatment started)	≥20% increase in the sum of diameters of target lesions. (two lesions per organ, maximum of five lesions) (reference: smallest sum recorded since treatment started)

Adapted with permission from Therasse P, et al. J Natl Cancer Inst 2000;92:205-216 and Lencioni R, et al. Semin Liver Dis 2010;30:52-60 [3].