Table 5a. Plasma PK comparisons from study 1 (CTT116415).

Component measured	Parameter	Treatment comparison	Treatment ratio (SE Loge) [90% CI for ratio]
FF	AUC(0–8) (h×pg/mL)	FF/UMEC/VI vs. FF/UMEC	1.05 (0.029) [1.00 – 1.10]
		FF/UMEC/VI vs. FF/VI	1.17 (0.029) [1.12 – 1.23]
	Cmax (pg/mL)	FF/UMEC/VI vs. FF/UMEC	1.01 (0.045) [0.94 – 1.09]
		FF/UMEC/VI vs. FF/VI	1.23 (0.045) [1.14 – 1.33]
UMEC	AUC(0–4) (h×pg/mL)	FF/UMEC/VI vs. FF/UMEC	0.99 (0.032) [0.94 – 1.04]
		FF/UMEC/VI vs. UMEC/VI	0.98 (0.032) [0.93 – 1.04]
	Cmax (pg/mL)	FF/UMEC/VI vs. FF/UMEC	1.09 (0.075) [0.97 – 1.24]
		FF/UMEC/VI vs. FUMEC/VI	0.99 (0.075) [0.87 – 1.12]
VI	AUC(0–2) (h×pg/mL)	FF/UMEC/VI vs. FF/VI	1.20 (0.023) [1.15 – 1.24]
		FF/UMEC/VI vs. UMEC/VI	1.18 (0.023) [1.13 – 1.22]
	Cmax (pg/mL)	FF/UMEC/VI vs. FF/VI	1.46 (0.037) [1.38 – 1.56]
		FF/UMEC/VI vs. UMEC/VI	1.33 (0.037) [1.25 – 1.42]

SE = standard error.