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. 2015 Aug 11;11:47. doi: 10.1186/s12990-015-0051-0

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© Ide et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effects of maprotiline on the antinociceptive effect of morphine under the UCMS condition. The effects of maprotiline on the thermal pain sensitivity (a) and the antinociceptive effect of morphine (3 mg/kg; b) in a hot-plate test under the UCMS (white column vehicle, n = 12; gray column maprotiline 3 mg/kg, n = 12; black column maprotiline 10 mg/kg, n = 14) and non-stress (white column vehicle, n = 14; gray column maprotiline 3 mg/kg, n = 12; black column maprotiline 10 mg/kg, n = 14) conditions. ^* p < 0.05, significantly differed from vehicle-injected UCMS mice. Data are expressed as mean ± SEM.