Table 1.

Definition of delayed response^*

Major criteria

No clinical improvement at 2 months treatment (e.g., fever, weight loss, etc)

No conversion of positive sputum AFB to negative at 2 months treatment

Minor criteria

Drug resistance of Mycobacterium tuberculosis

Associated illness compromising host immune response (e.g., diabetes mellitus, etc)

Endobronchial tuberculosis involving main bronchus

Pulmonary tuberculosis with extrapulmonary involvement

^*It needs at least one among major criteria and at least one among minor criteria.