Table 3.
Changes of serologic markers and cytokines during antituberculous treatment
| Time from chemotherapy | Before (N=18) | 2 months (N=18) | 6 months (N=18) |
|---|---|---|---|
| Body weight (kg) | 52.9±8.2 | 54.1±9.0 | 55.4±10.1 |
| Body mass index (kg/m2) | 19.5±2.4 | 20.0±2.7 | 20.4±2.9 |
| Hemoglobin† (g/dL) | 11.6±1.7 | 12.6±1.4 | 13.0±1.8* |
| Hematocrit† (%) | 34.7±4.9 | 37.8±3.6 | 38.2±4.7 |
| WBC count†† (×1,000/mm3) | 9.0±2.6 | 7.4±2.0 | 6.1±2.2** |
| Platelet count† (×1,000/mm3) | 379.8±132.6 | 313.8±115.8 | 278.9±107.1* |
| ESR††† (mm/hour) | 71.6±28.8 | 39.4±36.5* | 22.5±26.7*** |
| CRP††† (mg/dL) | 7.1±7.1 | 1.5±2.4** | 0.3±60.72*** |
| Ferritin (mg/dL) | 273.0±214.5 | 189.4±158.9 | 103.7±104.7* |
| LD (U/L) | 337.9±113.2 | 303.1± 54.3 | 317.8±59.1 |
| IL-1ra† (pg/mL) | 387.3±311.3 | 210.7±203.3 | 224.5±128.2 |
| IL-8 (pg/mL) | 1.59±2.95 | 3.8±16.48 | 2.13±5.87 |
Data are mean±SD.
†:
p<0.05,
††:
p<0.01,
†††:
p<0.001 by one-way ANOVA.
*:
p<0.05,
**:
p<0.01,
***:
p<0.001 vs. before treatment by multiple comparison using post-hoc test of Scheffe. ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; LD, lactate dehydrogenase; IL-1ra, interleukin-1 receptor antagonist; IL-8, interleukin-8