Table 2.
Comparison of characteristics of TSH receptor antibodies between patients with blocking TSHRAb and those without blocking TSHRAb in Graves’ disease
| TSBAb-positive (n=24) | TSBAb-negative (n=112) | |
|---|---|---|
| CHO TSAb activity (%) | 309 ± 182 | 518 ± 621* |
| FRTL-5 TSAb activity (%) | 1131 ± 1107 | 1022 ± 939 |
| Mc1+2 TSAb | ||
| positive cases | 6/24 | 17/112 |
| mean activity (%) | 214 ± 509 | 121 ± 103 |
| Mc2 TSAb | ||
| positive cases | 2/24 | 16/112 |
| mean activity (%) | 116 ± 105 | 188 ± 581* |
| TBII activity (%) | 52.3 ± 26.5 | 43.0 ± 22.5† |
Values are mean ± S.D.
CHO TSAb ; Stimulating TSHRAb activity measured by CHO-hTSHR cells
FRTL-5 TSAb ; Stimulating TSHRAb activity measured by FRTL-5 cells
TBII ; Thyrotropin binding inhibitor immunoglobulin
*
; p<0.05,
†
; p=0.06