Table 2.
Correlation between expression of TIMP-1 mRNA and clinicopathological parameters of hepatocellular carcinoma
| Clinicopathological Parameters | n | Intensity of TIMP-1 mRNA expression
|
P-value | |
|---|---|---|---|---|
| Weak(n) | Strong(n) | |||
| Age(years) | ||||
| <58 | 12 | 7 | 5 | 0.320 |
| ≥58 | 13 | 5 | 8 | |
| Sex | ||||
| Male | 19 | 11 | 8 | 0.078 |
| Female | 6 | 1 | 5 | |
| Basal liver disease | ||||
| Cirrhosis | 15 | 8 | 7 | 0.513 |
| Chronic hepatitis | 10 | 4 | 6 | |
| Tumor size(cm) | ||||
| <4.5 | 16 | 9 | 7 | 0.303 |
| ≥4.5 | 17 | 7 | 10 | |
| Differentiation grade* | ||||
| WD | 4 | 2 | 2 | 0.817 |
| MD | 12 | 5 | 7 | |
| PD | 9 | 5 | 4 | |
| Pattern of growth | ||||
| Infiltrative | 9 | 4 | 6 | 0.973 |
| Encapsulated | 16 | 7 | 8 | |
| Capsular invasion | ||||
| Absent | 11 | 5 | 6 | 0.590 |
| Present | 5 | 3 | 2 | |
| Satellite nodules | ||||
| Absent | 10 | 4 | 6 | 0.742 |
| Present | 15 | 7 | 8 | |
| Vascular invasion | ||||
| Absent | 17 | 8 | 9 | 0.891 |
| Present | 8 | 4 | 9 | |
*
WD; well differentiated, MD; moderately differentiated, PD; poorly differentiated