Table 2.
Distribution of HMGB1 SNPs in patients and controls
| Polymorphisms | Patients (N = 112) (%) | Controls (N = 118) (%) | OR (95% CI) | P value | Overall P value a |
|---|---|---|---|---|---|
| rs2249825 C/G | |||||
| Genotype | 0.046* | ||||
| CC | 55 (49.1) | 72 (61.0) | Ref. | ||
| CG | 25 (22.3) | 28 (23.7) | 1.17 (0.61–2.23) | 0.635 | |
| GG | 32 (28.6) | 18 (15.3) | 2.33 (1.18–4.58) | 0.013* | |
| Allele | |||||
| C | 135 (60.3) | 172 (72.9) | Ref. | ||
| G | 89 (39.7) | 64 (27.1) | 1.77 (1.20–2.62) | 0.004* | |
| rs1412125 T/C | |||||
| Genotype | 0.905 | ||||
| TT | 62 (55.4) | 66 (55.9) | Ref. | ||
| TC | 40 (35.7) | 41 (34.7) | 1.04 (0.60–1.81) | 0.894 | |
| CC | 10 (8.9) | 11 (9.4) | 0.97 (0.38–2.44) | 0.945 | |
| Allele | |||||
| T | 164 (73.2) | 173 (73.3) | Ref. | ||
| C | 60 (26.8) | 63 (26.7) | 1.01 (0.66–1.52) | 0.983 | |
*P value < 0.05. aOverall p-value across the three genotypes of a polymorphism