Table 1.

Changes of GBM components in Vacor-induced diabetic rats

(single close, 80mg/kg, PO)
Experimental period (days)	PAS	Collagen type IV	Laminin	Fibronectin	CSPG
Control	N	N	N	Nb	N
0.5	N	N	N	Nb	N
1	N	N	N	Nb	N
3	Na	+	+	+	+c
7	+	++	++	++	+c
14	++	+++	+++	+++	N
28	+++	+++	+++	+++	N
56	+++	++	+++	++	N

PO: per oral administration

CSPG: chondroitin sulfate proteoglycan

PAS: periodic acid Schiff stain

N: no change of GBM components compared with control rats

N^a: mild mesangial widening only

N^b: thin, segmental immunohistochemical reaction

+, ++, +++: degree of GBM component thickening (mild, moderate, severe)

+^c: mild segmental thickening