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The inhibition of CRC cell proliferation by 1,25(OH)2D3 and its analogs.
| LoVo | HT29 | HCT116 | ||||
|---|---|---|---|---|---|---|
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| Compound (nM) | MTT | SRB | MTT | SRB | MTT | SRB |
| 1α,25(OH)2D3 | 168 | 0.77 | 57 | 196 | 47 | 5.9 |
| Calcipotriol | 57 | 0.71 | ND | 4.6 | 5.3 | 3.7 |
| 25(OH)D3 | 6.6 | 35 | 319 | 49 | 457 | 243 |
The data are shown as IC50 values (nM) representing the concentration of the secosteroid which causes a 50% decrease in cell proliferation as measured by MTT and SRB assays. ND, not determined.
