Table 2.

Death due to clozapine-associated gastrointestinal hypomotility

Patient (sex, age [years])	Presentation	CLZ dose (mg/day)	Reference
M, 29	Aspiration of vomit secondary to obstruction of the transverse colon	400	Hayes and Gibler40
F, 31	Large bowel obstruction with mucosal necrosis, pulmonary edema, and shock	300	Thèret et al96
M, 49	Intermittent indigestion, nausea, chest pain, and vomiting. Collapsed with pulmonary edema secondary to inhalation of feculent vomit	500	Drew and Herdson97
M, 36	Necrotizing colitis	600	Shammi and Remington98
M, 43	History of ulcerative esophagitis. Abdominal pain, feculent vomiting, and severe fecal impaction with large intestinal necrosis	–	Levin et al99
M, 44	Found dead. evidence of pulmonary edema, paralytic ileus, and gastroenteritis	–	Ferslew et al100
F, 47	Large bowel infarct	–	Flanagan et al101

Note: –Data unavailable.

Abbreviations: CLZ, clozapine; M, male; F, female.