Table I.
Candidate genes for CDDP in ESCC cells.
| Cell | Identities | Gene | Overexpressed/downregulated |
|---|---|---|---|
| 4-2 | 98% | RPTOR | Overexpressed |
| 82% | JAK2 | Downregulated | |
| 4-4 | 100% | LRP1 | Downregulated |
| 100% | OR512 | Downregulated | |
| 4-7 | 97% | CNTNAP2 precursor | Downregulated |
| 96% | Protein CASP isoform | Downregulated | |
| 93% | IL-6 precursor | Overexpressed | |
| 15-5 | 83% | CAMKMT | Downregulated |
| 90% | TRIM16L | Overexpressed | |
| 78% | PDE8B | Downregulated | |
| 83% | DENND3 | Downregulated | |
| 92% | ZFPM2 | Downregulated | |
| 80% | UMODL1 | Downregulated | |
| 86% | TRAV26-2 | Overexpressed | |
| 84% | CAMSAP2 | Downregulated | |
| 80% | TNFSF4 | Overexpressed | |
| 15-8 | 100% | ASTN2 | Downregulated |
| 100% | KIAA0368 | Overexpressed | |
| 94% | RFX3 isoform | Downregulated | |
| 100% | AQP7 | Overexpressed | |
| 100% | GNA14 | Downregulated | |
| 100% | OR1N2 | Overexpressed | |
| 100% | INTS9 isoform | Downregulated | |
| 100% | RNF19a | Downregulated | |
| 15-14 | 86% | TSHSD7B | Downregulated |
| 94% | PTBP1 | Downregulated | |
| 90% | MVB12B | Downregulated | |
| 100% | HEPHL1 precursor | Downregulated | |
| 82% | NELL1 isoform | Downregulated | |
| 96% | FHAD1 | Downregulated | |
| 87% | PCDH7 | Downregulated | |
| 92% | ROBO2 isoform/precursor | Downregulated | |
| 92% | RFPL3 | Downregulated | |
| 15-15 | 92% | MICAL4 | Downregulated |
| 15-19 | 89% | LRRC38 | Overexpressed |
| 89% | RAB3B | Downregulated | |
| 100% | SYT10 | Downregulated |
A total of 39 candidate genes from 8 resistant colonies were identified. CDDP, cisplatin; ESCC, esophageal squamous cell carcinoma.