. Author manuscript; available in PMC: 2016 Jun 1.

Published in final edited form as: J Mol Cell Cardiol. 2015 Apr 11;83:1–13. doi: 10.1016/j.yjmcc.2015.04.005

Table 3.

Chronic Alterations in Scruture Function are Similar in Aging and Experimental Left Ventricualr Pressure Loading (From Ref. 52)

Structural or Functional Measure Measure	Experimental LV Pressure Loading (Rodent)	Normotensive Aging (Rodent)
Myocardial cell size	↑	↑
Collagen content	↑	↑
Twitch duration	↑	↑
Myosin isozyme composition	↓β₁ ↑β₃	↓β₁ ↑β₃
SR Ca²⁺ pumping rate	↓	↓
Ca_i transient duration	↑	↑
Myofilament Ca²⁺ sensitivity	↔	↔
Actional potential repolarization time	↑	↑
B-adrenergic intropic response	↓	↓
Cardiac glycoside response	↓	↓
Threshold for Ca²⁺ overload	↓	↓