Table 4.

Distribution of cases and controls, allele frequency and odds ratios with 95% confidence intervals for three single-nucleotide polymorphisms (SNPs) in five case–control studies

	Cases	Controls	OR	95% CI
SERPINC1 gene – rs2227589
MEGA2*	1294† (0.12)‡	2836† (0.10)‡	1.29§	1.11, 1.49
GWAS¶	419 (0.12)	1228 (0.10)	1.23	0.96, 1.57
MARTHA¶	1150 (0.11)	801 (0.11)	1.00	0.82, 1.23
FARIVE¶	607 (0.10)	607 (0.10)	1.00	0.77, 1.30
GATE**	544 (0.11)	664 (0.11)	1.07	0.83, 1.39
		OR†† = 1.15 (1.05, 1.26)
CYP4V2 gene – rs13146272
MEGA2	1160 (0.69)	2624 (0.64)	1.24	1.12, 1.38
GWAS	419 (0.67)	1228 (0.63)	1.19	1.01, 1.40
MARTHA	1150 (0.64)	801 (0.62)	1.09	0.96, 1.24
FARIVE	607 (0.63)	607 (0.61)	1.09	0.92, 1.28
GATE	544 (0.66)	661 (0.62)	1.22	1.03, 1.44
		OR = 1.17 (1.10, 1.25)
GP6 gene – rs1613662
MEGA2	1299 (0.84)	2848 (0.82)	1.14	1.01, 1.30
GWAS	419 (0.87)	1228 (0.85)	1.18	0.94, 1.48
MARTHA	1150 (0.86)	801 (0.85)	1.08	0.90, 1.30
FARIVE	607 (0.87)	607 (0.84)	1.27	1.01, 1.60
GATE	546 (0.85)	663 (0.84)	1.04	0.84, 1.30
		OR = 1.14 (1.05, 1.23)

^*From reference [1].

^†Number of subjects (n) in study.

^‡Prevalence of the risk allele in 2N gametes (Table 1 defines risk allele).

^§Odds of risk allele in cases divided by the corresponding odds in control (2N gametes).

^¶From reference [10].

^**The present study, White subjects only.

^††Summary odds ratio over the five studies.