Table 4.
Percent Differences in Cortical Section Modulus in Each Disease Group, Compared with Controls
| Base Model | Base Adjusted for Muscle CSA | Base Adjusted for Muscle CSA and Muscle Torque | Base Adjusted for Muscle CSA, Muscle Torque, and Weight | |||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Percent Difference (95% CI) | p | Percent Difference (95% CI) | p | Percent Difference (95% CI) | p | Percent Difference (95% CI) | p | |
|
| ||||||||
| R2 = 0.88 95%CI: (0.86, 0.91) |
R2 = 0.92 95% CI: (0.90, 0.94) |
R2 = 0.92 95% CI: (0.91, 0.94) |
R2 = 0.92 95% CI: (0.91, 0.94) |
|||||
| CKD 2–3 | −7.0 (−13,4, −0.1) | 0.048 | −5.2 (−10.5, 0.5) | 0.08 | −3.6 (−9.1, 2.3) | 0.22 | −4.6 (−9.9, 1.1) | 0.11 |
| CKD 4–5D | −11.5 (−18.6, −3.7) | 0.005 | −6.7 (−12.9, 0.0) | 0.05 | −4.5 (−11.0, 2.4) | 0.19 | −5.9 (−12.1, 0.1) | 0.09 |
| Ln(muscle CSA) | + | < 0.001 | + | < 0.001 | + | < 0.001 | ||
| Ln(muscle torque) | + | 0.007 | + | 0.03 | ||||
| Ln(weight) | + | < 0.001 | ||||||
|
| ||||||||
|
R2 = 0.89 95% CI: (0.86, 0.91) |
R2 = 0.93 95% CI: (0.91, 0.94) |
R2 = 0.93 95% CI: (0.92, 0.95) |
R2 = 0.93 95% CI: (0.92, 0.95) |
|||||
|
| ||||||||
| Nephrotic Syndrome | 3.2 (−2.3, 9.1) | 0.26 | 1.3 (−3.2, 5.9) | 0.59 | 1.5 (−2.9, 6.1) | 0.50 | 0.1 (−4.2, 4.6) | 0.95 |
| Ln(muscle CSA) | + | < 0.001 | + | < 0.001 | + | < 0.001 | ||
| Ln(muscle torque) | + | < 0.001 | + | 0.004 | ||||
| Ln(weight) | + | < 0.001 | ||||||
|
| ||||||||
|
R2 = 0.87 95% CI: (0.84, 0.90) |
R2 = 0.92 95% CI: (0.90, 0.93) |
R2 = 0.92 95% CI: (0.90, 0.93) |
R2 = 0.92 95% CI: (0.91, 0.94) |
|||||
|
| ||||||||
| Crohn Disease PCDAI ≤ 30 | −2.7 (−9.8, 4.9) | 0.47 | 4.7 (−1.5, 11.2) | 0.14 | 4.8 (−1.3, 11.3) | 0.12 | 4.5 (−1.4, 10.8) | 0.14 |
| PCDAI > 30 | −4.7 (−10.8, 1.7) | 0.15 | 6.3 (0.6, 12.2) | 0.03 | 7.4 (1.7, 13.3) | 0.01 | 6.8 (1.3, 12.6) | 0.01 |
| Ln(muscle CSA) | + | < 0.001 | + | < 0.001 | + | < 0.001 | ||
| Ln(muscle torque) | + | 0.001 | + | 0.004 | ||||
| Ln(weight) | + | < 0.001 | ||||||
The results represent the percent difference in cortical section modulus in the disease group, compared with the controls. All models are adjusted for age, age2, tibia length, sex, Tanner stage by sex interaction, race, and Tanner stage by race interaction.
+
The β coefficients for muscle CSA and muscle torque are not provided as these are continuous variables and not expressed as percent differences in Zp between participant groups. The plus symbol represents the direction of the association.