Table 7.
Frequency of genotypes in the study population
| Study group
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| n | All | n | Unexposed Controls | n | Organic Farmers | n | Pesticide workers | p-value | |
| EPHX1 codon 113 | |||||||||
| Tyr/Tyr | 116 | 64.4% | 41 | 67.2% | 21 | 60.0% | 54 | 64.3% | 0.913 |
| Tyr/His | 45 | 25.0% | 15 | 24.6% | 9 | 25.7% | 21 | 25.0% | |
| His/His | 19 | 10.6% | 5 | 8.2% | 5 | 14.3% | 9 | 10.7% | |
|
| |||||||||
| EPHX1 codon 139 | |||||||||
| His/His | 100 | 54.9% | 37 | 60.7% | 21 | 58.3% | 42 | 49.4% | 0.673 |
| His/Arg | 71 | 39.0% | 20 | 32.8% | 13 | 36.1% | 38 | 44.7% | |
| Arg/Arg | 11 | 6.0% | 4 | 6.6% | 2 | 5.6% | 5 | 5.9% | |
|
| |||||||||
| GSTM1 deletion | |||||||||
| positive | 90 | 49.5% | 31 | 50.8% | 15 | 41.7% | 44 | 51.8% | 0.577 |
| null | 92 | 50.5% | 30 | 49.2% | 21 | 58.3% | 41 | 48.2% | |
|
| |||||||||
| GSTT1 deletion | |||||||||
| positive | 155 | 85.2% | 53 | 86.9% | 28 | 77.8% | 74 | 87.1% | 0.379 |
| null | 27 | 14.8% | 8 | 13.1% | 8 | 22.2% | 11 | 12.9% | |
|
| |||||||||
| GSTP1 codon 105 | |||||||||
| Ile/Ile | 74 | 40.7% | 21 | 34.4% | 13 | 36.1% | 40 | 47.1% | 0.354 |
| Ile/Val | 84 | 46.2% | 31 | 50.8% | 20 | 55.6% | 33 | 38.8% | |
| Val/Val | 24 | 13.2% | 9 | 14.8% | 3 | 8.3% | 12 | 14.1% | |
|
| |||||||||
| XRCC1 codon 194 | |||||||||
| Arg/Arg | 167 | 91.8% | 60 | 98.4% | 32 | 88.9% | 75 | 88.2% | 0.202 |
| Arg/Trp | 14 | 7.7% | 1 | 1.6% | 4 | 11.1% | 9 | 10.6% | |
| Trp/Trp | 1 | 0.5% | 0 | 0.0% | 0 | 0.0% | 1 | 1.2% | |
|
| |||||||||
| XRCC1 codon 399 | |||||||||
| Arg/Arg | 62 | 34.1% | 19 | 31.1% | 14 | 38.9% | 29 | 34.1% | 0.843 |
| Arg/Gln | 83 | 45.6% | 28 | 45.9% | 17 | 47.2% | 38 | 44.7% | |
| Gln/Gln | 37 | 20.3% | 14 | 23.0% | 5 | 13.9% | 18 | 21.2% | |
|
| |||||||||
| XRCC2 codon 188 | |||||||||
| Arg/Arg | 129 | 70.9% | 49 | 80.3% | 27 | 75.0% | 53 | 62.4% | 0.068 |
| Arg/His | 50 | 27.5% | 10 | 16.4% | 9 | 25.0% | 31 | 36.5% | |
| His/His | 3 | 1.6% | 2 | 3.3% | 0 | 0.0% | 1 | 1.2% | |