Table 3.
ERmax, ERNa, and natriuresis efficiency after oral torasemide-IR 10 mg, furosemide-IR 40 mg, and torasemide-PR 10 mg (N=9)
| Parameter | Torasemide-IR | Furosemide-IR | Torasemide-PR |
|---|---|---|---|
| ERmax (μg/h)* | |||
| Arithmetic mean (SD) | 555.24 (205.0) | 3,186.84 (1,410.1) | 404.38 (79.5) |
| Median (min–max) | 533.52 (324.3–913.2) | 2,798.85 (1,091.6–5,316.5) | 416.99 (262.3–503.0) |
| ERNa (mmol/h) | |||
| Arithmetic mean (SD) | 82.61 (28.6) | 81.63 (38.5) | 83.19 (37.1) |
| Median (min–max) | 87.01 (40.0–119.0) | 78.02 (36.5–143.8) | 65.33 (41.5–138.5) |
| Natriuresis efficiency* (mmol/μg) | |||
| Arithmetic mean (SD) | 0.091 (0.024) | 0.015 (0.007) | 0.096 (0.03) |
| Median (min–max) | 0.08 (0.06–0.13) | 0.017 (0.01–0.03) | 0.1 (0.06–0.13) |
Note:
*
P<0.0001 (both torasemide formulations vs furosemide). Data are the mean (SD) and median (min-max) of the pharmacodynamic parameters obtained for the three formulations.
Abbreviations: ERmax, drug’s excretion rate; ERNa, sodium excretion rate; h, hour; IR, immediate release; max, maximum; min, minimum; PR, prolonged release; SD, standard deviation.