Table 5.
PK/PD urinary parameters (N=9)
| Parameter | Torasemide-IR | Furosemide-IR | Torasemide-PR |
|---|---|---|---|
| Ae24 (μg) | |||
| Arithmetic mean (SD) | 1,805.14 (502.8) | 13,586.26 (4,061.2) | 2,020.50 (757.4) |
| Median (min–max) | 1,700.29 (1,145.7–2,961.4) | 15,346.48 (5,620.4–18,586.0) | 2,146.61 (1,052.6–3,688.1) |
| P-value | |||
| Torasemide-IR | – | <0.0001 | 0.214 |
| Furosemide-IR | – | – | <0.0001 |
| Torasemide-PR | – | – | – |
| Ae∞ (μg) | |||
| Arithmetic mean (SD) | 1,869.75 (512.8) | 13,953.82 (3,887.4) | 2,109.94 (765.6) |
| Median (min–max) | 1,831.38 (1,160.2–3,024.3) | 15,672.18 (6,347.8–18,757.1) | 2,223.9 (1,085.02–3,768.1) |
| P-value | |||
| Torasemide-IR | – | <0.0001 | 0.155 |
| Furosemide-IR | – | – | <0.0001 |
| Torasemide-PR | – | – | – |
| ERK (mmol/h) | |||
| Arithmetic mean (SD) | 29.75 (9.6) | 33.51 (8.6) | 29.08 (10.1) |
| Median (min–max) | 31.98 (16.7–45.5) | 32.21 (22.81–44.40) | 26.45 (18.2–50.8) |
| P-value | |||
| Torasemide-IR | – | 0.588 | 0.996 |
| Furosemide-IR | – | – | 0.435 |
| Torasemide-PR | – | – | – |
| ERCl (mmol/h) | |||
| Arithmetic mean (SD) | 98.69 (30.0) | 93.46 (40.0) | 95.06 (38.4) |
| Median (min–max) | 110.96 (53.0–131.0) | 101.55 (36.4–147.0) | 74.46 (54.3–152.2) |
| P-value | |||
| Torasemide-IR | – | 0.678 | 0.939 |
| Furosemide-IR | – | – | 0.994 |
| Torasemide-PR | – | – | – |
Notes: Data are mean (SD) and median (min-max) for every pharmacokinetic and pharmacodynamic parameter. Significance for parameters was tested by means of a one-way analysis of variance (ANOVA) followed by a post hoc analysis to assess differences by pairs. Bold values indicate statistical significance.
Abbreviations: Ae24, cumulative amount of drug excreted up to 24 hours; Ae∞, cumulative amount of drug excreted up to infinity; ERK, potassium excretion rate; ERCl, chlorine excretion rate; h, hour; max, maximum; min, minimum; PK/PD, pharmacokinetic/pharmacodynamic; IR, immediate-release; PR, prolonged release; SD, standard deviation.