Table 1.
The stability of KBP-7018 in plasma and microsomes (n=2)
| Parameter | Human | Cynomolgus monkey | Beagle dog | SD rat | CD-1 mouse |
|---|---|---|---|---|---|
| Remaining concentrationa (%) | 108.7 | 103.7 | 105.3 | 67.2 | 85.2 |
| CLint (mL/min/mg)b | 0.09 | 0.44 | 0.12 | 0.07 | 0.04 |
| CLHepatic,predicted (mL/min/kg)c | 4.2 | 18.4 | 6.4 | 5.6 | 7.2 |
Notes:
a
Remaining concentration in plasma after incubation.
b
Intrinsic clearance in liver microsomes.
c
Predicted hepatic clearance by the well-stirred model.
Abbreviation: SD, Sprague-Dawley; CL, clearance.