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In vitro PPB% and BPP of KBP-7018 (n=2)
| Parameter | Human | Cynomolgus monkey | Beagle dog | SD rat | CD-1 mouse |
|---|---|---|---|---|---|
| PPB% (2 μM) | 99 | 99 | 99 | 99 | 99 |
| PPB% (20 μM) | 99 | 99 | 99 | 99 | 99 |
| BPP | 0.84 | – | 0.84 | 1.27 | 0.84 |
Abbreviations: PPB, plasma protein binding; BPP, blood–plasma partitioning; SD, Sprague-Dawley.
