Table 4.
Comparative permeability of KBP-7018 and nintedanib
| Compound | Concentration (μM) |
Papp (10−6 cm/s)
|
Efflux ratio | |
|---|---|---|---|---|
| A to B | B to A | |||
| Nintedanib | 2 | 0.05 | 14.42 | 319.81 |
| 20 | 0.29 | 22.55 | 78.24 | |
| KBP-7018 | 2 | 0.43 | 1.14 | 2.64 |
| 20 | 0.04 | 0.05 | 1.15 | |
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